I thought this was an interesting article, especially since there's been alot of buzz about coffee and it's protective benefits relating to diabetes. Coffee contains hundreds of active phytochemicals which have been shown to exhibit protective benefit. However, the article discusses that the caffeine in coffee, when consumed with a high fat meal (ie. coffee and a muffin for breakfast, or coffee and a doughnut) the two can have additive "insulin de-sensitizing" effects. The article also states that: "The only reason coffee is beneficial is because of the severe deficiencies in the plant-derived phytochemicals in the diet of most Americans, and coffee at least supplies something." (Fuhrman)
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